John Ewer, Associate Professor

Current Publications


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Publications

Paré, A. C. and Ewer J. Constructing deletions with defined endpoints in Drosophila using P-elements in trans. Submitted.

Dulcis D, Levine R, Ewer J. 2005. Role of the neuropeptide CCAP in Drosophila cardiac function. J. Neurobiol. In press.

Luo, C.-W., Dewey, E. M., Sudo, S., Ewer, J., Hsu, S. Y., Honegger, H.-W., and Hsueh, A. J. W. (2005). Bursicon, the insect cuticle hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2. Proc. Natl. Acad. Sci. USA 102, 2820-2825.

Dewey, E.M*, S.L. McNabb*, J. Ewer, G.R. Kuo, C.L. Takanishi, J.W. Truman and H.-W. Honegger. (2004). Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreading. Curr. Biol. 14:1208-1213. (*) Co-first authors. Commentary: Chong, L.D. 2004. Acquiring a tan. Science 305:575.

Clark AC*, M.L. Del Campo*, and J. Ewer. (2004). Neuroendocrine control of larval ecdysis behavior in Drosophila: complex regulation by partially redundant neuropeptides. J. Neuroscience 24:4283-4292. (*) Co-first authors. Commentary: Casci, T. 2004. Shedding degeneracies. Nat. Rev. Genet. 5:488.

Husain, Q. M., and Ewer, J. (2004). Use of targetable gfp-tagged neuropeptide for visualizing neuropeptide release following execution of a behavior in Drosophila. J. Neurobiol. 59, 181-191.

Park, J., A. J. Schroeder, C. Helfrich-Förster, F. R. Jackson and J. Ewer (2003). Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of behavior. Development 130: 2645-2656.

Draizen, T., Ewer, J., and Robinow, S. (1999) Genetic and hormonal regulation of the death of peptidergic neurons in the Drosophila central nervous system. J. Neurobiol. 38: 455-465.

Ewer, J., Wang, C.-W., Klukas, K.A., Mesce, K.A., Truman, J.W., and Fahrbach, S.E. (1998) Programmed cell death of identified peptidergic neurons involved in ecdysis behavior in the moth, Manduca sexta, J. Neurobiol., 37: 265-280.

Ewer, J. and Truman, J.W. (1997) Invariant association of ecdysis with increases in cyclic 3',5'-guanosine monophosphate (cGMP) immunoreactivity in a small network of peptidergic neurons in the hornworm, Manduca sexta. J. Comp. Physiology A, 181: 319-330.

Ewer, J., Gammie, S.C., and Truman, J.W. (1997) Control of insect ecdysis by a positive feedback endocrine system: roles of eclosion hormone and eclosion triggering hormone. J. Exp. Biol., 200: 869-881.

Ewer, J. and Truman, J.W. (1996) Increases in cyclic GMP occur at ecdysis in an evolutionarily conserved insect neuronal network. J. Comp. Neurol., 370: 330-341.

Truman, J.W., Ewer, J., and Ball, E.E. (1996) Dynamics of cyclic GMP changes in identified neurones during ecdysis behavior in the locust, Locusta migratoria. J. Exp. Biol., 199: 749-758.

Ewer, J., De Vente, J., and Truman, J.W. (1994) Neuropeptide induction of cyclic GMP increases in the insect CNS: resolution at the level of single identifiable neurons. J. Neurosci., 12: 7704-7712.

Horodysky, F.M., Ewer, J., Riddiford, L.M. and Truman, J.W. (1993) Isolation, characterization, and expression of the eclosion hormone gene of Drosophila melanogaster. Eur. J. Biochem. 215: 221-228.

Ewer, J., Frisch, B., Hamblen-Coyle, M.J., Rosbash, M. and Hall, J.C. (1992) Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells' influence on circadian behavioral rhythms. J. Neurosci. 12: 3321-3349.

Ewer, J., Hamblen-Coyle, M.J., Rosbash, M. and Hall, J.C. (1990) Requirement for period gene expression in the adult and not during development for locomotor activity rhythms of imaginal Drosophila melanogaster. J. Neurogenetics, 7: 31-73

Ewer, J., Rosbash, M. and Hall, J.C. (1988). An inducible promoter fused to the period gene in Drosophila conditionally rescues adult per-mutant arrhythmicity. Nature 333: 82-84.

James, A.A., Ewer, J. Reddy, P., Hall, J.C. and Rosbash, M. (1986). Embryonic expression of the period gene in the central nervous system of Drosophila melanogaster. EMBO J. 5: 2313-2320.

Hooper, S.L., O'Neil M.B., Wagner, R., Ewer, J., Golowash, J. and Marder, E. (1986). The innervation of the pyloric region of the crab, Cancer borealis: homologous muscles in decapod species are differently innervated. J. Comp. Physiol A 159: 227-240.

Reviews

Ewer, J. (2005). Behavioral actions of neuropeptides in invertebrates: insights from Drosophila. Hormones and Behavior. Submitted.

Ewer, J. and Reynolds, S. (2002) Neuropeptide control of molting in insects. In: Hormones, Brain and Behavior. Vol. 3, Ch. 35, D. Pfaff, Editor-in-Chief. Vol. 3, Ch. 35, pp. 1-92.

Ewer, J. and Sokolowski, M.B. (1998). Drosophila. In: Encyclopedia of reproduction. E. Knobil  and J.D. Neill, Eds. Academic Press. Vol. 1.

Recent abstracts

Ewer, J. del Campo, M., and Clark, A.C. (2003) Control of ecdysis behavior: evidence for complex and partially-redundant neuropeptide regulation. Neurobiology of Drosophila. Cold Spring Harbor, New York.

Ewer, J. (2003). Neuropeptide control of insect ecdysis behavior. First International meeting of the Latin-American Society of Developmental Biology. Santiago, Chile.

Ewer, J. Park, J., Schroeder, A.J., Helfrich-Förster, C., F. Rob Jackson (2003). Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of behavior. 44th Annual Drosophila research conference. Chicago.